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KMID : 0525720090140040188
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Journal of Chitin and Chitosan
2009 Volume.14 No. 4 p.188 ~ p.191
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Antioxidative Property of β-chitooligosaccharides Against H2O2-induced Oxidative Stress
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Lee Seung-Jae
Kim Eun-Kyung
Ahn Hye-Won
Hwang Jin-Woo
Park Pyo-Jam
Sung Si-Heung
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Abstract
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In this study, we investigated the protective effect of β-chitooligosaccharides (β-COSs) against hydrogen peroxide (H2O2)-
induced oxidative stress, and its effect on antioxidative enzyme activity in vitro. We prepared three kinds of β-COSs with
different molecular weights: higher molecular weights (HMWβ-COSs: 50~10 kDa), medium molecular weights (MMWβ-
COSs: 10~5 kDa), and lower molecular weight (LMWβ-COSs: below 5 kDa). The results showed that MMWβ-COSs
exhibited the most preventive property of cell apoptosis induced by H2O2. The protective effect of MMWβ-COSs on free
radical-induced DNA damage exhibited 62% at 1.0 mg/mL. In addition, antioxidative enzyme levels in cultured liver cells
were increased in the presence of MMWβ-COSs. These results indicate that MMWβ-COSs shows potent antioxidative
activity.
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KEYWORD
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β-chitooligosaccharides, molecular weights, oxidative stress, antioxidative activity
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